- 45 (number)
- the years 45 BC, 45 AD, 1945, 2045
In film
- 45 (film), directed by Peter Coster (2009)
- .45 (film), directed by Gary Lennon (2006)
- Love and a .45, directed by C.M. Talkington (1994)
In music
- 45 (Jaguares album), 2008
- 45 (Kino album), 1982
- "45" (The Gaslight Anthem song), 2012
- "45" (Shinedown song), 2003
- "45", a song by Elvis Costello from the album When I Was Cruel (2002)
- A 45 RPM gramophone record
Other uses
- 45 (book), written by Bill Drummond
- .45 ACP pistol cartridge
- A nickname for a handgun chambered in .45 caliber, such as the M1911 pistol or Colt Single Action Army
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